Anthranilate phosphoribosyltransferase

anthranilate phosphoribosyltransferase
Identifiers
EC number 2.4.2.18
CAS number 9059-35-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, an anthranilate phosphoribosyltransferase (EC 2.4.2.18) is an enzyme that catalyzes the chemical reaction

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate \rightleftharpoons anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate

Thus, the two substrates of this enzyme are N-(5-phospho-D-ribosyl)-anthranilate and diphosphate, whereas its two products are anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase. Other names in common use include phosphoribosyl-anthranilate pyrophosphorylase, PRT, anthranilate 5-phosphoribosylpyrophosphate, phosphoribosyltransferase, anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase, phosphoribosylanthranilate pyrophosphorylase, phosphoribosylanthranilate transferase, and anthranilate-PP-ribose-P phosphoribosyltransferase. This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis and two-component system - general.

Structural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1GXB, 1KGZ, 1KHD, 1O17, 1V8G, 1VQU, 1ZVW, 1ZXY, 1ZYK, 2BPQ, 2ELC, and 2GVQ.

References